Department of Medical Neurobiology, IMRIC, The Hebrew University-Hadassah Medical School Jerusalem, Israel ; The Interdisciplinary Center for Neural Computation, The Hebrew University Jerusalem, Israel ; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University Jerusalem, Israel ; The Research Laboratory of Brain Imaging and Stimulation, The Jerusalem Mental Health Center, Kfar-Shaul Etanim, Hebrew University-Hadassah Medical School Jerusalem, Israel.
Front Syst Neurosci. 2013 Nov 19;7:79. doi: 10.3389/fnsys.2013.00079. eCollection 2013.
Beta-band synchronous oscillations in the dorsolateral region of the subthalamic nucleus (STN) of human patients with Parkinson's disease (PD) have been frequently reported. However, the correlation between STN oscillations and synchronization has not been thoroughly explored. The simultaneous recordings of 2390 multi-unit pairs recorded by two parallel microelectrodes (separated by fixed distance of 2 mm, n = 72 trajectories with two electrode tracks >4 mm STN span) in 57 PD patients undergoing STN deep brain stimulation surgery were analyzed. Automatic procedures were utilized to divide the STN into dorsolateral oscillatory and ventromedial non-oscillatory regions, and to quantify the intensity of STN oscillations and synchronicity. Finally, the synchronicity of simultaneously vs. non-simultaneously recorded pairs were compared using a shuffling procedure. Synchronization was observed predominately in the beta range and only between multi-unit pairs in the dorsolateral oscillatory region (n = 615). In paired recordings between sites in the dorsolateral and ventromedial (n = 548) and ventromedial-ventromedial region pairs (n = 1227), no synchronization was observed. Oscillation and synchronicity intensity decline along the STN dorsolateral-ventromedial axis suggesting a fuzzy border between the STN regions. Synchronization strength was significantly correlated to the oscillation power, but synchronization was no longer observed following shuffling. We conclude that STN long-range beta oscillatory synchronization is due to increased neuronal coupling in the Parkinsonian brain and does not merely reflect the outcome of oscillations at similar frequency. The neural synchronization in the dorsolateral (probably the motor domain) STN probably augments the pathological changes in firing rate and patterns of subthalamic neurons in PD patients.
在帕金森病（PD）患者的丘脑底核（STN）背外侧区域中，经常报道β带同步振荡。然而，STN 振荡与同步之间的相关性尚未得到彻底探索。对 57 名接受 STN 深部脑刺激手术的 PD 患者的 2 个平行微电极（间隔固定距离 2mm，n=72 个轨迹的 2 个电极轨迹>4mmSTN 跨度）同时记录的 2390 个多单位对进行了分析。利用自动程序将 STN 分为背外侧振荡区和腹侧非振荡区，并量化 STN 振荡和同步的强度。最后，使用重排程序比较同时记录和非同时记录对的同步性。同步性主要观察到在β频带中，并且仅在背外侧振荡区的多单位对之间（n=615）观察到。在背外侧和腹侧（n=548）以及腹侧-腹侧（n=1227）记录对之间的配对记录中，未观察到同步性。振荡和同步性强度沿着 STN 背外侧-腹侧轴下降，表明 STN 区域之间存在模糊边界。同步性强度与振荡功率显著相关，但重排后不再观察到同步性。我们得出结论，STN 长程β振荡同步是由于帕金森氏脑神经元耦合增加所致，而不仅仅反映了相似频率的振荡结果。STN 背外侧（可能是运动域）的神经同步性可能会增强 PD 患者 STN 神经元放电率和模式的病理变化。
