西伯花锚和毛萼山罗花的抗氧化及抗菌活性
Antioxidant and Antimicrobial activity of Pedicularis sibthorpii Boiss. And Pedicularis wilhelmsiana Fisch ex.
作者信息
Khodaie Laleh, Delazar Abbas, Lotfipour Farzaneh, Nazemiyeh Hossein
机构信息
Drugs Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. ; Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Adv Pharm Bull. 2012;2(1):89-92. doi: 10.5681/apb.2012.012. Epub 2012 Apr 15.
PURPOSE
This research paper presents antioxidant and antimicrobial activities of Pedicularis sibthorpii and Pedicularis wilhelmsiana which grow in Azerbaijan/Iran with claimed a lot of therapeutic effects.
METHODS
DPPH assay and agar well diffusion method were carried out to determine antioxidant and antimicrobial activities respectively.
RESULTS
Methanolic extract showed better antioxidant activity compared to other crude extracts (n-hexane and dichloromethane). Methanolic extracts of both Pedicularis sibthorpii and Pedicularis wilhelmsiana were found to have antibacterial activity especially against gram positive strains of S. ureus, S.epidermidis. No antifungal activity was observed in the tested extracts.
CONCLUSION
Existence of some phenolic compounds in methanolic extracts, such as phenylethanoids and flavonoids (found in other species of Pedicularis), which cause both antioxidant and antibacterial activities, is probable. Antimicrobial and antioxidant activity of the methanolic extracts supports further studies related to phytochemical investigation and bioassay of different fractions to isolate pure compounds of plants.
目的
本研究论文介绍了生长在阿塞拜疆/伊朗的西伯花楸和毛花洋地黄的抗氧化和抗菌活性，据称它们具有多种治疗作用。
方法
分别采用DPPH法和琼脂扩散法测定抗氧化和抗菌活性。
结果
与其他粗提物（正己烷和二氯甲烷）相比，甲醇提取物显示出更好的抗氧化活性。发现西伯花楸和毛花洋地黄的甲醇提取物均具有抗菌活性，尤其对革兰氏阳性菌金黄色葡萄球菌、表皮葡萄球菌。在所测试的提取物中未观察到抗真菌活性。
结论
甲醇提取物中可能存在一些酚类化合物，如苯乙醇类和黄酮类（在其他花楸属植物中发现），它们导致了抗氧化和抗菌活性。甲醇提取物的抗菌和抗氧化活性支持了进一步开展与植物化学研究以及不同馏分的生物测定以分离植物纯化合物相关的研究。
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