维拉帕米与地高辛对心房颤动心率控制的比较。
A comparison of verapamil and digoxin for heart rate control in atrial fibrillation.
作者信息
Afzali Moghadam Mohammad, Fadaie Dashti Maryam, Shahsavarinia Kavous, Mahmoodpoor Ata, Jamali Kazem
机构信息
Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Adv Pharm Bull. 2012;2(2):201-5. doi: 10.5681/apb.2012.031. Epub 2012 Aug 15.
PURPOSE
Atrial fibrillation (AF) is one of the most common types of sustained dysrhythmia and there are some disagreements about its treatment. The goals of AF treatment include the control of ventricular rate, the establishment of sinus rhythm and the prevention of thromboembolic events. In this study, the effect of verapamil was compared to digoxin on heart rate control in patients with AF.
METHODS
This descriptive study was conducted in an emergency department (ED) in Iran. Sixty patients with a new onset AF and rapid ventricular response receiving digoxin or verapamil were included and observed.
RESULTS
Two thirty-patient groups receiving verapamil or digoxin were evaluated. The heart rate was significantly decreased in both groups (p = 0.002); however, the cardioversion was not noticed in both of them. The best rate control in verapamil and digoxin groups was observed after 5.9 mg (46.7%) and 0.6 mg (36.7%), respectively.
CONCLUSION
Administration of verapamil in comparison with digoxin has no difference to control the heart rate in AF patients. It should be taken into consideration that prospective randomized studies should be conducted to identify the efficacy and select the best of these two drugs to treat AF patients.
目的
心房颤动（AF）是最常见的持续性心律失常类型之一，其治疗存在一些争议。AF治疗的目标包括控制心室率、恢复窦性心律以及预防血栓栓塞事件。在本研究中，比较了维拉帕米和地高辛对AF患者心率控制的效果。
方法
本描述性研究在伊朗的一家急诊科进行。纳入并观察了60例新发AF且心室反应快速并接受地高辛或维拉帕米治疗的患者。
结果
对接受维拉帕米或地高辛治疗的两个30例患者的组进行了评估。两组心率均显著降低（p = 0.002）；然而，两组均未观察到复律情况。维拉帕米组和地高辛组分别在给予5.9 mg（46.7%）和0.6 mg（36.7%）后观察到最佳心率控制效果。
结论
与地高辛相比，维拉帕米在控制AF患者心率方面无差异。应考虑进行前瞻性随机研究以确定这两种药物治疗AF患者的疗效并选择最佳药物。
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