Mohammadzadeh Ramin, Ahmadiyan Nejla
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ; Students Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Adv Pharm Bull. 2013;3(1):247-8. doi: 10.5681/apb.2013.040. Epub 2013 Feb 7.
Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) cause difficulties in the management of skin and soft tissue infections and have led to morbidity and mortality in hospital-acquired infections especially in susceptible individuals, those who are generally sick or immunosuppressed. Currently approaches in antibacterial agents offer opportunities to manage the trouble using novel anti-infection systems. Therefore, nanotechnology, a most promising field for generating new applications in medicine, has introduced a most prominent nanoproduct named as nanosilver that revealed excellent antimicrobial activity against some of the hazardous infections. Also cathelicidin peptides which are a part of native immune defense system in the skin and epithelia exhibit excellent antimicrobial activity against some of these perilous infections.
铜绿假单胞菌和耐甲氧西林金黄色葡萄球菌(MRSA)给皮肤和软组织感染的治疗带来困难,并导致医院获得性感染的发病和死亡,尤其是在易感个体中,即那些通常生病或免疫抑制的人。目前,抗菌药物的方法为使用新型抗感染系统来解决这一问题提供了机会。因此,纳米技术作为医学领域最有前途的新应用领域,推出了一种最突出的纳米产品——纳米银,它对一些危险感染显示出优异的抗菌活性。此外,作为皮肤和上皮组织天然免疫防御系统一部分的cathelicidin肽对其中一些危险感染也表现出优异的抗菌活性。