Talebi Mahnaz, Andalib Sasan, Bakhti Shohreh, Ayromlou Hormoz, Aghili Alireza, Talebi Ashraf
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Adv Pharm Bull. 2013;3(2):283-8. doi: 10.5681/apb.2013.046. Epub 2013 Aug 20.
Carpal tunnel syndrome (CTS) refers to a cluster of signs and symptoms that stems from compression of the median nerve traveling through carpal tunnel. Surgery is a definite treatment for CTS; however, many conservative therapies have been proposed. The present study set out to assess the effect of vitamin B6 in patients with CTS.
Forty patients (67 hands) with mild-moderate CTS were initially selected and randomly assigned into two groups as follows: 1) Case group with 20 subjects (32 affected hands) receiving vitamin B6 (120 mg/day for 3 months) and splinting. 2) Control group with 19 subjects (35 affected hands) only received splinting. One subject from the control group dispensed with continuing participation in the research. Daily symptoms and electrodiagnostic (NCV-EMG) results were assessed at baseline and after 3 months.
Nocturnal awakening frequency due to pain, daily pain, daily pain frequency, daily pain persistence, hand numbness, hand weakness, hand tingling, severity of nocturnal numbness and tingling, nocturnal awakening frequency owing to hand numbness and tingling, and clumsiness in handling objects improved significantly in the vitamin B6-treated patients; even so, only problem with opening a jam bottle and handling phone significantly reduced in the control group. The median nerve sensory latency mean decreased following the treatment; and the median nerve sensory amplitude mean and sensory conduction velocity mean increased.
The present study suggests that vitamin B6 treatment improves clinical symptoms and sensory electrodiagnostic results in CTS patients, and thus is recommended for CTS treatment.
腕管综合征（CTS）是指一系列由正中神经在腕管内受压引起的体征和症状。手术是CTS的明确治疗方法；然而，也提出了许多保守治疗方法。本研究旨在评估维生素B6对CTS患者的疗效。
最初选择40例（67只手）轻度至中度CTS患者，并随机分为两组：1）病例组，20名受试者（32只患手）接受维生素B6（120毫克/天，持续3个月）和夹板固定。2）对照组，19名受试者（35只患手）仅接受夹板固定。对照组中有1名受试者放弃继续参与研究。在基线和3个月后评估每日症状和电诊断（神经传导速度-肌电图）结果。
维生素B6治疗的患者因疼痛导致的夜间觉醒频率、每日疼痛、每日疼痛频率、每日疼痛持续时间、手部麻木、手部无力、手部刺痛、夜间麻木和刺痛的严重程度、因手部麻木和刺痛导致的夜间觉醒频率以及操作物体时的笨拙程度均有显著改善；即便如此，对照组中只有打开果酱瓶和操作手机的问题显著减少。治疗后正中神经感觉潜伏期平均值降低；正中神经感觉振幅平均值和感觉传导速度平均值增加。
本研究表明，维生素B6治疗可改善CTS患者的临床症状和感觉电诊断结果，因此推荐用于CTS治疗。
