Eftekharsadat Bina, Babaei-Ghazani Arash, Habibzadeh Afshin
Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.
Iran J Pharm Res. 2015 Fall;14(4):1275-80.
Carpal tunnel syndrome (CTS) is a neuropathy due to the compression of the median nerve. It is shown that gabapentin in high doses is effective in treatment of CTS patients. In this study we evaluated the efficacy of low doses of gabapentin in treatment of CTS patients. Ninety patients with CTS were randomly assigned to groups A, B and C. Gabapentin was administered to group A with dose of 100 mg/day and to group B with dose of 300 mg/day for 2 months. Group C received no treatment. Before and after treatment, patients were evaluated using Visual analogue scale (VAS) for pain and parasthesia, Boston carpal tunnel questionnaire (BCTQ) including Symptom Severity Scale (SSS) and Functional Status Scale (FSS) to evaluate the efficacy of the treatment. The pinch and grip strength was also measured. There was significant improvement in VAS, grip strength, pinch strength, SSS, FSS and BCTQ score in all three groups (p < 0.05), but the changes in CMAP and SNAP was not significant. Groups A and B in comparison to group C had significantly better improvement in VAS, pinch strength, SSS, FSS and BCTQ total score (p < 0.05). There was significantly more improvement in pinch strength and SSS score in group B compared to group A (p < 0.05). Gabapentin in low doses is a useful drug in treatment of CTS symptoms with no side effects and intolerance. Gabapentin with dose of 300 mg/day is more effective than the dose of 100 mg/day.
腕管综合征（CTS）是一种由于正中神经受压引起的神经病变。研究表明，高剂量加巴喷丁对CTS患者的治疗有效。在本研究中，我们评估了低剂量加巴喷丁对CTS患者的治疗效果。90例CTS患者被随机分为A、B、C三组。A组给予加巴喷丁100mg/天，B组给予加巴喷丁300mg/天，持续2个月。C组不接受治疗。治疗前后，使用视觉模拟评分法（VAS）评估疼痛和感觉异常，使用波士顿腕管综合征问卷（BCTQ），包括症状严重程度量表（SSS）和功能状态量表（FSS）来评估治疗效果。同时测量捏力和握力。三组患者的VAS、握力、捏力、SSS、FSS和BCTQ评分均有显著改善（p<0.05），但复合肌肉动作电位（CMAP）和感觉神经动作电位（SNAP）的变化不显著。与C组相比，A组和B组在VAS、捏力、SSS、FSS和BCTQ总分方面的改善明显更好（p<0.05）。与A组相比，B组在捏力和SSS评分方面的改善明显更多（p<0.05）。低剂量加巴喷丁是治疗CTS症状的有效药物，无副作用和不耐受现象。300mg/天剂量的加巴喷丁比100mg/天剂量更有效。
