[Tissue responses to silicone materials in the body].

Light microscopy was used to study connective tissue capsules formed around different silicone breast implants. It has been found that due to the activity of microfibroblasts to minimize the volume of foreign bodies, the capsule gradually shrinks; its inner surface deforms and develops an undulating appearance with a multitude of outgrowths or protrusions inside. With the passage of time, silicone migrates to the capsule tissue and outside where it is absorbed by phagocytes. The inerter to a living organism the implant material is, the less it will stimulate a macrophage response. The task of designing new implants is to search for maximally bioinert materials that are strong enough to be compressed by the capsule and be fragmented and, moreover, elastically similar to normal breast tissue.