Busch H
Baylor College of Medicine, Houston, TX 77030.
Semin Arthritis Rheum. 1994 Aug;24(1 Suppl 1):11-7. doi: 10.1016/0049-0172(94)90104-x.
Silicone, a man-made polymer containing the element silicon, has been used in a variety of medical devices including breast implants. Silicone was used, in part, because it was suggested to have the property of biological inertness. Inert materials do not affect chemical, physiological, or immunological processes. Silicone is not inert. Silicone from breast implants "bleeds" through the surrounding envelope and is present in the surrounding capsule or migrates to other distant locations. Silicone and/or the multiple chemical contaminants elicit foreign body reactions associated with granulomatous inflammation and fibrosis. Silicone and its contaminants have the potential for significant toxicity in the implant recipient.
硅酮是一种含硅元素的人造聚合物，已被用于包括乳房植入物在内的各种医疗设备中。使用硅酮的部分原因是有人认为它具有生物惰性。惰性材料不会影响化学、生理或免疫过程。但硅酮并非惰性。乳房植入物中的硅酮会透过周围包膜“渗出”，存在于周围的包膜中或迁移到其他远处位置。硅酮和/或多种化学污染物会引发与肉芽肿性炎症和纤维化相关的异物反应。硅酮及其污染物对植入接受者有潜在的重大毒性。
