具有修饰侧链的OSW-1类似物的合成及其抗肿瘤活性。
Synthesis of OSW-1 analogs with modified side chains and their antitumor activities.
作者信息
Deng Lehua, Wu Hao, Yu Biao, Jiang Manrong, Wu Jiarui
机构信息
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
出版信息
Bioorg Med Chem Lett. 2004 Jun 7;14(11):2781-5. doi: 10.1016/j.bmcl.2004.03.081.
Four analogs of OSW-1 (1-4) with modified side chains on the steroidal skeleton were synthesized following modification of our previous route for the total synthesis of OSW-1. Testing of the analogs against growth of tumor cells demonstrated that the 22-one function and the full length of the side chain of OSW-1 were not required for the antitumor action of OSW-1.
在改进我们之前全合成OSW-1的路线后，合成了甾体骨架上侧链经修饰的4种OSW-1类似物（1-4）。对这些类似物抑制肿瘤细胞生长的测试表明，OSW-1的抗肿瘤作用并不需要22-酮官能团和OSW-1侧链的全长。
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