Lašaitė L, Ceponis J, Preikša R T, Zilaitienė B
Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Andrologia. 2014 Dec;46(10):1107-12. doi: 10.1111/and.12199. Epub 2013 Dec 8.
The study aimed to analyse emotional state, quality of life and cognitive functions in young hypogonadal men. Thirty-four males with hypogonadism (age 29.1 ± 10.5 years) and 34 age-matched healthy males (age 30.5 ± 11.0 years) were recruited. Their emotional state was evaluated by Profile of Mood States, quality of life - by WHO Brief Quality of Life Questionnaire - and cognitive functioning - by Trail Making Test and Digit Span Test of Wechsler Adult Intelligence Scale. It was found that young men with hypogonadism had higher depression-dejection (13.1 ± 8.8 versus 7.4 ± 5.9, P = 0.003), fatigue-inertia (10.0 ± 5.8 versus 7.0 ± 4.9, P = 0.030), confusion-bewilderment (5.1 ± 4.6 versus 2.3 ± 3.1, P = 0.004) and lower vigour-activity (14.3 ± 5.1 versus 17.7 ± 4.3, P = 0.008) levels than age- and sex-matched controls. Quality of life psychological (13.1 ± 2.8 versus 15.1 ± 1.9, P = 0.005) and social (13.6 ± 2.4 versus 15.7 ± 2.0, P < 0.001) domains were significantly worse in men with hypogonadism than in controls. Cognitive functions were significantly worse (P < 0.001) in men with hypogonadism than in controls, showing worse executive function, attention, visual scanning abilities and psychomotor speed. A significant correlation was found between testosterone concentration and quality of life psychological domain. Cognitive functioning scores were significantly related with FT4 concentration. It is concluded that young hypogonadal patients have impaired emotional state and quality of life, but the most severe impairment was found in cognitive functioning.
该研究旨在分析性腺功能减退的年轻男性的情绪状态、生活质量和认知功能。招募了34名性腺功能减退男性（年龄29.1±10.5岁）和34名年龄匹配的健康男性（年龄30.5±11.0岁）。通过情绪状态剖面图评估他们的情绪状态，通过世界卫生组织生活质量简表评估生活质量，通过韦氏成人智力量表的连线测验和数字广度测验评估认知功能。结果发现，性腺功能减退的年轻男性在抑郁沮丧（13.1±8.8对7.4±5.9，P = 0.003）、疲劳惰性（10.0±5.8对7.0±4.9，P = 0.030）、困惑迷茫（5.1±4.6对2.3±3.1，P = 0.004）方面得分更高，而在活力活动（14.3±5.1对17.7±4.3，P = 0.008）方面得分更低，与年龄和性别匹配的对照组相比。性腺功能减退男性的生活质量心理领域（13.1±2.8对15.1±1.9，P = 0.005）和社会领域（13.6±2.4对15.7±2.0，P < 0.001）明显比对照组差。性腺功能减退男性的认知功能明显比对照组差（P < 0.001），表现为执行功能、注意力、视觉扫描能力和精神运动速度更差。发现睾酮浓度与生活质量心理领域之间存在显著相关性。认知功能得分与游离甲状腺素（FT4）浓度显著相关。结论是，年轻的性腺功能减退患者情绪状态和生活质量受损，但认知功能受损最为严重。
