Zhang Li-ying, Gao Lan-xiang, Liu Guang, Yang Guang-zhi, Cheng Juan, Ding Hua-ye
Department of Pathology, the Military General Hospital of BeiJing PLA, Beijing 100700, China.
Zhonghua Bing Li Xue Za Zhi. 2013 Sep;42(9):599-603.
To investigate the clinicopathologic features, clinical progress and prognosis of the basal-like subtype of invasive lobular carcinoma (ILC) of the breast.
Four cases of ILC were analyzed by detailed histopathologic observation and immunohistochemical staining for E-cadherin, p120 catenin, ER, PR, HER2, CK5/6, EGFR, p63, p53, Ki-67 using MaxVision method. The follow-up and clinical data were analyzed.
Morphologically, one case was mixed ILC and three cases were pleomorphic ILC. The tumor cells were negative for E-cadherin except one case with focal membrane positivity, and all showed p120 catenin cytoplasmic positivity except one case with focal membrane positivity. All cases were negative for ER, PR and HER2 (triple negative), and positive for EGFR and CK5/6. Two cases were positive for p63. The cases were partly and weakly positive for p53, and the Ki-67 positive rate was between 30% and 75%. Follow-up data showed that two cases developed chest wall metastases, and in one case, there was progression to liver and abdominal metastases.
ILC of the breast are ER, PR and HER2 "triple negative", CK5/6 and EGFR positive, indicative of basal-like characteristics. Basal-like subtype of ILC are peculiarly prone to metastasis and poor response to chemotherapy, suggesting that it is associated with poor prognosis.
探讨乳腺浸润性小叶癌（ILC）基底样亚型的临床病理特征、临床进展及预后。
对4例ILC进行详细的组织病理学观察，并采用MaxVision法对E-钙黏蛋白、p120连环蛋白、雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体2（HER2）、细胞角蛋白5/6（CK5/6）、表皮生长因子受体（EGFR）、p63、p53、Ki-67进行免疫组化染色。分析随访及临床资料。
形态学上，1例为混合性ILC，3例为多形性ILC。除1例灶性膜阳性外，肿瘤细胞E-钙黏蛋白均为阴性，除1例灶性膜阳性外，所有病例p120连环蛋白均呈胞质阳性。所有病例ER、PR和HER2均为阴性（三阴性），EGFR和CK5/6阳性。2例p63阳性。病例p53呈部分弱阳性，Ki-67阳性率在30%至75%之间。随访数据显示，2例发生胸壁转移，1例进展为肝转移和腹部转移。
乳腺ILC为ER、PR和HER2“三阴性”，CK5/6和EGFR阳性，具有基底样特征。ILC的基底样亚型特别容易发生转移，对化疗反应不佳，提示其预后不良。
