Ilić Ivan R, Petrović Aleksandar, Živković Vesna V, Randjelović Pavle J, Stojanović Nikola M, Radulović Niko S, Randjelović Dušica, Ilić Ratko S
Institute of Pathology, Faculty of Medicine, University of Niš, Niš, Serbia.
Department of Histology, Faculty of Medicine, University of Niš, Niš, Serbia.
Adv Med Sci. 2017 Mar;62(1):78-82. doi: 10.1016/j.advms.2016.07.003. Epub 2017 Feb 10.
Patient age, tumor size, axillary lymph node status, expression of estrogen, progesterone and HER2 receptors, as well as the histological grade, are widely accepted prognostic and predictive parameters in breast carcinoma. In invasive lobular carcinoma (ILC), the prognostic factors, such as nodal status and tumor size are believed to be the most valuable ones. The aim of this was set to determine the possible linkage between MFity/MCity of ILC and immunohistochemical predictive (ER, PR, HER2) and prognostic parameters (BRCA1, p53, E-cadherin, Ki-67).
MATERIAL/METHODS: Out of 2486 cases diagnosed with BC from south-eastern Serbia, the presence ILC was noted in 334 cases. Immunohistochemical characterization of predictive and prognostic parameters in ILC was done.
The occurrence of multifocal (MFC) and multicentric carcinoma (MCC) was observed in 18.9% of ILC. Bilateral (BL) BCs were found to be statistically significantly more frequent in younger women, compared to those with MFC, MCC or nonMFC/MCC/BL. No significant correlation was found between MFC/MCC and the presence of axillary lymph node metastases, and expression of immunohistochemical predictive and prognostic parameters. Based on literature data and the findings from the current work, MFity/MCtiy might represent negative morphologic prognostic parameters in ILC.
In 334 cases analyzed, no statistically significant correlations were observed between MF/MC and the expression of immunohistochemical predictive and prognostic parameters.
患者年龄、肿瘤大小、腋窝淋巴结状态、雌激素、孕激素及人表皮生长因子受体2（HER2）的表达，以及组织学分级，是乳腺癌广泛认可的预后和预测参数。在浸润性小叶癌（ILC）中，诸如淋巴结状态和肿瘤大小等预后因素被认为是最有价值的因素。本研究旨在确定ILC的多灶性/多中心性与免疫组化预测指标（雌激素受体、孕激素受体、HER2）及预后参数（乳腺癌1号基因、p53、E-钙黏蛋白、Ki-67）之间的可能联系。
材料/方法：在塞尔维亚东南部诊断为乳腺癌的2486例病例中，发现334例存在ILC。对ILC的预测和预后参数进行了免疫组化特征分析。
在18.9%的ILC中观察到多灶性癌（MFC）和多中心癌（MCC）。与MFC、MCC或非MFC/MCC/双侧性乳腺癌患者相比，双侧乳腺癌在年轻女性中更为常见，差异有统计学意义。未发现MFC/MCC与腋窝淋巴结转移的存在以及免疫组化预测和预后参数的表达之间存在显著相关性。基于文献数据和当前研究结果，多灶性/多中心性可能代表ILC的阴性形态学预后参数。
在分析的334例病例中，未观察到MFC/MCC与免疫组化预测和预后参数的表达之间存在统计学显著相关性。
