Wang Meng-xing, Wang Xin, Zhang Zhi, Qin Man
Department of Pediatrics, Peking University School and Hospital of Stomatology,Beijing 100081, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Sep;48(9):545-9.
To detect the salivary factors related to caries and periodontal disease and to analyze the risk of caries and periodontal disease in children and adolescents with diabetes mellitus.
The study comprised 30 children with diabetic mellitus, aged 7-15 years old, and 60 healthy age-and gender-matched children. Caries and periodontal indexes were recorded and saliva related factors were analyzed.
Caries indexes of diabetes children [permanent teeth: decay missing filling tooth (DMFT) M (Q1,Q3) = 0(0, 4), deciduous teeth: decay missing filling tooth (dmft) M (Q1,Q3) = 0(0, 1)] were not significantly different with those of healthy children [DMFT M (Q1,Q3) = 1(0, 3), dmft M (Q1,Q3) = 0(0, 4)], but plaque index (PLI) (1.25 ± 0.33) and bleeding index (BI) (0.74 ± 0.45) of diabetes children were significantly higher than those of healthy children (PLI was 0.93 ± 0.31,BI was 0.34 ± 0.22) (P < 0.001). Salivary pH of diabetes children (7.68 ± 0.36) was significantly higher than that of healthy children (7.30 ± 0.32) (P < 0.05), and salivary acid buffering capacity had no significant difference between the two groups (P > 0.05). Salivary glucose, immunoglobulin sIgA and sIgG were not significantly different between the two groups (P > 0.05).Salivary lysozyme of diabetes children was significantly higher than that of healthy children (P < 0.05). Total protein was significantly lower in diabetes children than in healthy children (P < 0.05). Salivary lactate dehydrogenase had no significant difference between the two groups (P > 0.05).
Diabetes mellitus can lead to the changes of some salivary factors related to gingivitis in diabetes children. Children and adolescents with diabetes mellitus may have a higher risk of periodontal disease.
检测与龋病和牙周疾病相关的唾液因子，并分析糖尿病患儿和青少年患龋病和牙周疾病的风险。
该研究纳入了30名7至15岁的糖尿病患儿以及60名年龄和性别匹配的健康儿童。记录龋病和牙周指数，并分析唾液相关因子。
糖尿病患儿的龋病指数[恒牙：龋失补牙数（DMFT）中位数（四分位数间距）=0（0，4），乳牙：龋失补牙数（dmft）中位数（四分位数间距）=0（0，1）]与健康儿童[DMFT中位数（四分位数间距）=1（0，3），dmft中位数（四分位数间距）=0（0，4）]相比无显著差异，但糖尿病患儿的菌斑指数（PLI）（1.25±0.33）和出血指数（BI）（0.74±0.45）显著高于健康儿童（PLI为0.93±0.31，BI为0.34±0.22）（P<0.001）。糖尿病患儿的唾液pH值（7.68±0.36）显著高于健康儿童（7.30±0.32）（P<0.05），两组间唾液酸缓冲能力无显著差异（P>0.05）。两组间唾液葡萄糖、免疫球蛋白sIgA和sIgG无显著差异（P>0.05）。糖尿病患儿的唾液溶菌酶显著高于健康儿童（P<0.05）。糖尿病患儿的总蛋白显著低于健康儿童（P<0.05）。两组间唾液乳酸脱氢酶无显著差异（P>0.05）。
糖尿病可导致糖尿病患儿一些与牙龈炎相关的唾液因子发生变化。糖尿病患儿和青少年可能患牙周疾病的风险更高。
