Wirz-Justice A
Schweiz Arch Neurol Psychiatr (1985). 1986;137(5):87-96.
Circadian rhythms are found in all living organisms, and represent a physiological correlate of the geophysical rhythm of day and night. These rhythms are endogenous in nature, driven by a pacemaker in the hypothalamus, and synchronized to the 24-hour day. Many of the symptoms of affective illness can be considered in terms of altered timing of circadian rhythms. Furthermore, total or partial sleep deprivation or phase advance of the sleep-wake cycle can induce remission (albeit temporary) in many depressive patients, and antidepressant drugs influence circadian rhythm characteristics. Bright light may have antidepressant properties in certain seasonally recurring depressives.
昼夜节律存在于所有生物中，代表着昼夜地球物理节律的一种生理关联。这些节律本质上是内源性的，由下丘脑的一个起搏器驱动，并与24小时的一天同步。情感性疾病的许多症状可以从昼夜节律时间改变的角度来考虑。此外，完全或部分睡眠剥夺或睡眠-觉醒周期的相位提前可在许多抑郁症患者中诱导缓解（尽管是暂时的），并且抗抑郁药物会影响昼夜节律特征。强光在某些季节性复发的抑郁症患者中可能具有抗抑郁特性。
