Wehr T A, Rosenthal N E, Sack D A, Gillin J C
Acta Psychiatr Scand. 1985 Aug;72(2):161-5. doi: 10.1111/j.1600-0447.1985.tb02589.x.
In order to test whether exposure to bright artificial light at night is a necessary condition for the antidepressant response to sleep deprivation therapy, five patients were totally sleep-deprived on two separate nights, once in very bright light and once in nearly total darkness. During the day after the sleep-deprivation night patients were found to have responded equally well to sleep deprivation in both conditions. During the sleep-deprivation night, however, antidepressant responses may have been greater in the bright light condition. Thus, light at night is not necessary for the antidepressant response to sleep deprivation, but we cannot rule out the possibility that the effects of light exposure and sleep deprivation are additive or that exposure to light at some time after sleep deprivation begins (including during the following day) is necessary for the response.
为了测试夜间暴露于明亮的人造光是否是睡眠剥夺疗法产生抗抑郁反应的必要条件，五名患者在两个不同的夜晚完全被剥夺睡眠，一次是在非常明亮的光线下，一次是在几乎完全黑暗的环境中。在睡眠剥夺夜晚后的白天，发现患者在两种情况下对睡眠剥夺的反应同样良好。然而，在睡眠剥夺的夜晚，明亮光线下的抗抑郁反应可能更强。因此，夜间光照并非睡眠剥夺产生抗抑郁反应的必要条件，但我们不能排除光照和睡眠剥夺的效果具有叠加性的可能性，也不能排除在睡眠剥夺开始后的某个时间（包括随后的白天）暴露于光照对反应是必要的可能性。
