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通过睡眠-觉醒周期的相位提前增强抗抑郁药物的作用。

Potentiation of antidepressant medications by phase advance of the sleep-wake cycle.

作者信息

Sack D A, Nurnberger J, Rosenthal N E, Ashburn E, Wehr T A

出版信息

Am J Psychiatry. 1985 May;142(5):606-8. doi: 10.1176/ajp.142.5.606.

DOI:10.1176/ajp.142.5.606
PMID:3985199
Abstract

Four patients with major depression who were unresponsive to antidepressant medications rapidly improved and remained euthymic after an advance of the sleep-wake cycle. Phase advance of the sleep-wake cycle and antidepressant treatment may have complementary effects on the circadian system. The authors suggest that the combination may be useful in treating drug nonresponders and in hastening response to antidepressant drugs.

摘要

4名对抗抑郁药物无反应的重度抑郁症患者在睡眠-清醒周期提前后迅速改善并保持心境正常。睡眠-清醒周期提前与抗抑郁治疗可能对昼夜节律系统具有互补作用。作者们认为，二者联合可能有助于治疗药物无反应者并加速对抗抑郁药物的反应。

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