Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Division of Nuclear Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Psychiatry Res. 2014 Jan 30;221(1):92-6. doi: 10.1016/j.pscychresns.2013.11.005. Epub 2013 Nov 22.
Single-photon emission-computed tomography (SPECT) after the administration of (99m)Tc-TRODAT-1 was performed on healthy subjects and subjects with methamphetamine (METH)dependence at time 1 (T1) after 24-48 h of abstinence, time 2 (T2) after 2 weeks of abstinence, and time 3 (T3) after 4 weeks of abstinence. In contrast to values in controls, the values of the striatal DAT specific uptake ratios (SURs) in subjects with METH dependence were significantly lower at T1 (n=25), T2 (n=9), and T3 (n=8); a mild increase in SURs was observed at T2 and T3, but values were still significantly lower than those in controls. In subjects with METH dependence, there was a trend for a negative correlation of striatal DAT SURs and craving for METH at T1. METH craving, anxiety and depression scores significantly decreased from T1 to T2 to T3. We conclude that Han Chinese people with METH dependence experience significant striatal DAT dysfunction, and that these changes may be mildly reversible after 4 weeks of abstinence, but that DAT levels still remain significantly lower than those in healthy subjects. The mild recovery of striatal DAT may parallel improvements in craving, anxiety and depression.
在经过 24-48 小时的戒毒后，对健康受试者和甲基苯丙胺（METH）依赖受试者在时间 1（T1）、时间 2（T2）和时间 3（T3）进行单光子发射计算机断层扫描（SPECT），并给予（99m）Tc-TRODAT-1。与对照组相比，METH 依赖受试者的纹状体多巴胺转运蛋白（DAT）特异性摄取率（SURs）在 T1（n=25）、T2（n=9）和 T3（n=8）时明显降低；在 T2 和 T3 时，SURs 有轻微增加，但仍明显低于对照组。在 METH 依赖受试者中，纹状体 DAT SURs 与 METH 渴求在 T1 时呈负相关的趋势。METH 渴求、焦虑和抑郁评分从 T1 到 T2 到 T3 显著降低。我们的结论是，中国人 METH 依赖者经历了显著的纹状体 DAT 功能障碍，并且这些变化在戒毒 4 周后可能会轻度可逆，但 DAT 水平仍然明显低于健康受试者。纹状体 DAT 的轻度恢复可能与渴求、焦虑和抑郁的改善平行。
