Depression Research Unit, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
J Affect Disord. 2012 Dec 10;141(2-3):425-31. doi: 10.1016/j.jad.2012.03.007. Epub 2012 Apr 4.
We examined striatal dopamine transporter (DAT) distribution volume ratio (DVR) values in subjects with unipolar or bipolar major depressive episode (versus non-depressed healthy volunteers) using the selective DAT radioligand [(99m)Tc]TRODAT-1 and single photon emission computed tomography (SPECT). We hypothesized that striatal DVR values would be greater in depressed versus non-depressed subjects, and that greater DVR values may represent a possible clinical biomarker of depression.
[(99m)Tc]TRODAT-1 spect images were acquired from 39 depressed and 103 non-depressed drug-free subjects. The primary outcome measure was the DVR value of [(99m)Tc]TRODAT-1 binding for the putamen region and the combined putamen plus caudate region.
DVR values were significantly correlated across all striatal regions within both subject groups (p<0.005). Depressed subjects had significantly greater DVR values (versus non-depressed subjects) in the putamen (p<0.0005) and the combined putamen plus caudate (p<0.0005) regions. There was no difference in DVR values between unipolar (n=24) and bipolar (n=15) depressed subjects, and no difference in DVR values for depressed subjects with or without prior antidepressant exposure. The predictive probability of the putamen or combined putamen plus caudate DVR value to distinguish depressed from non-depressed subjects was significant (p<0.0005).
DAT values could potentially be influenced by age, gender, diagnosis, prior psychotropic dug exposure, illness length, or symptom severity.
Results confirm prior observations of greater striatal DAT density in depressed versus non-depressed subjects, and suggest that greater DVR values may possibly represent a potential diagnostic biomarker for distinguish depressed from non-depressed individuals.
我们使用选择性多巴胺转运蛋白（DAT）放射性配体[(99m)Tc]TRODAT-1 和单光子发射计算机断层扫描（SPECT）检查了单相或双相重性抑郁发作（MDD）与非抑郁健康志愿者的纹状体多巴胺转运体（DAT）分布容积比（DVR）值。我们假设抑郁患者的纹状体 DVR 值会大于非抑郁患者，并且较大的 DVR 值可能代表抑郁的潜在临床生物标志物。
从 39 名抑郁患者和 103 名非抑郁无药物治疗的受试者中采集[(99m)Tc]TRODAT-1spect 图像。主要结局测量是纹状体苍白球区和纹状体苍白球加尾状核区[(99m)Tc]TRODAT-1 结合的 DVR 值。
在所有纹状体区域，两组受试者的 DVR 值均显著相关（p<0.005）。与非抑郁患者相比，抑郁患者的纹状体苍白球（p<0.0005）和纹状体苍白球加尾状核（p<0.0005）区的 DVR 值显著更大。单相（n=24）和双相（n=15）抑郁患者的 DVR 值无差异，也没有观察到有或无抗抑郁药物暴露的抑郁患者的 DVR 值有差异。苍白球或纹状体苍白球加尾状核 DVR 值区分抑郁与非抑郁患者的预测概率具有显著意义（p<0.0005）。
DAT 值可能受到年龄、性别、诊断、先前精神药物暴露、疾病持续时间或症状严重程度的影响。
结果证实了先前观察到的抑郁患者的纹状体 DAT 密度大于非抑郁患者，并且表明较大的 DVR 值可能代表区分抑郁与非抑郁个体的潜在诊断生物标志物。
