Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, 37, Guo Xue Road, Chengdu 610041, Sichuan Province, China.
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, 37, Guo Xue Road, Chengdu 610041, Sichuan Province, China.
Clin Res Hepatol Gastroenterol. 2014 Apr;38(2):226-34. doi: 10.1016/j.clinre.2013.10.011. Epub 2013 Dec 4.
X-ray repair cross-complementing group 3 (XRCC3) is responsible for maintaining the integrity of the genome, playing a critical role in protecting it against mutations which lead to cancer. Polymorphisms at exons 7 of the XRCC3 gene may alter the XRCC3 repair efficiency. The aim of this study is to derive a precise estimation of the relationship between XRCC3 Thr241Met polymorphism and gastric cancer (GC) risk.
Two investigators independently searched the databases of Pubmed, EMBASE and China National Knowledge Infrastructure (CNKI) up to May 15, 2013. Odds ratio (OR) and 95% confidence intervals (CI) for XRCC3 Thr241Met polymorphism and GC were calculated in a fixed- or random- effects model depending on statistical heterogeneity.
This meta-analysis included 9 case-control studies, which included 2209 cases and 3269 controls. Overall, the combined results based on all studies indicated that there was no association between XRCC3 Thr241Met polymorphism and GC susceptibility for all genetic models. When stratifying for race, we found the 241Met/Met genotype carriers might be at high risk of GC among Asians, but not among Caucasians. When stratifying by the location of gastric cancer, the combined results showed that Met/Met genotype carriers might have an increased risk of GC in non-cardiac gastric cancer, but not in cardiac cancer.
This meta-analysis confirmed that the XRCC3 Thr241Met gene polymorphism might be a risk factor for GC among Asians, and that differences in genotype distribution may be related to the location of gastric cancer. More well-designed studies based on larger population are needed to confirm our results.
X 射线修复交叉互补基因 3（XRCC3）负责维持基因组的完整性，在保护基因组免受导致癌症的突变方面起着关键作用。XRCC3 基因外显子 7 上的多态性可能改变 XRCC3 的修复效率。本研究旨在准确评估 XRCC3 Thr241Met 多态性与胃癌（GC）风险之间的关系。
两位研究者独立检索了 Pubmed、EMBASE 和中国知网（CNKI）数据库，截至 2013 年 5 月 15 日。采用固定效应模型或随机效应模型，根据统计异质性，计算 XRCC3 Thr241Met 多态性与 GC 的比值比（OR）和 95%置信区间（CI）。
本 meta 分析共纳入 9 项病例对照研究，包括 2209 例病例和 3269 例对照。总体而言，所有研究的综合结果表明，XRCC3 Thr241Met 多态性与 GC 易感性之间无关联，无论采用何种遗传模型。按种族分层时，我们发现 241Met/Met 基因型携带者患 GC 的风险可能较高，但在白种人中并非如此。按胃癌部位分层时，综合结果显示，Met/Met 基因型携带者患非贲门胃癌的风险可能增加，但在贲门癌中并非如此。
本 meta 分析证实，XRCC3 Thr241Met 基因多态性可能是亚洲人群 GC 的危险因素，基因型分布的差异可能与胃癌的部位有关。需要更多基于更大人群的精心设计的研究来证实我们的结果。
