Wang Zhe, Chen Xu, Liu Bo, Li Shide, Liu Mingjun, Xue Hong
Division of Spine and Osteopathy Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Tumour Biol. 2014 Feb;35(2):1589-98. doi: 10.1007/s13277-013-1219-8. Epub 2013 Oct 3.
Gastric cancer is one of the most prevalent types of cancer in the world today. Recently, there is a large sample volume of published case-control studies on XRCC3 Thr241Met polymorphism with gastric cancer. This will have an important impact on published article by meta-analysis regarding XRCC3 Thr241Met polymorphism with gastric cancer. Therefore, it is necessary to update by meta-analysis to comprehensively investigate the relationship between DNA repair gene XRCC3 Thr241Met polymorphism and gastric cancer. To preciously examine the association between the XRCC3 Thr241Met polymorphism and gastric cancer, we undertook a meta-analysis of 12 case-control studies. The association between the XRCC3 Thr241Met polymorphism and gastric cancer risk was assessed by odds ratios together with their 95 % confidence intervals using a fixed-effects model or random-effects model. We found that the XRCC3 Thr241Met polymorphism was not associated with an increased gastric cancer risk. However, the XRCC3 Thr241Met polymorphism was associated with decreased gastric cancer risk in Asians. In addition, there is no evidence of association on XRCC3 Thr241Met polymorphism with response to chemotherapy and prognosis in gastric cancer. The XRCC3 Thr241Met polymorphism might influence gastric cancer risk in Asians.
胃癌是当今世界上最常见的癌症类型之一。最近，有大量已发表的关于XRCC3 Thr241Met多态性与胃癌的病例对照研究。这将对关于XRCC3 Thr241Met多态性与胃癌的荟萃分析发表文章产生重要影响。因此，有必要通过荟萃分析进行更新，以全面研究DNA修复基因XRCC3 Thr241Met多态性与胃癌之间的关系。为了精确检验XRCC3 Thr241Met多态性与胃癌之间的关联，我们对12项病例对照研究进行了荟萃分析。使用固定效应模型或随机效应模型，通过比值比及其95%置信区间评估XRCC3 Thr241Met多态性与胃癌风险之间的关联。我们发现，XRCC3 Thr241Met多态性与胃癌风险增加无关。然而，XRCC3 Thr241Met多态性与亚洲人胃癌风险降低有关。此外，没有证据表明XRCC3 Thr241Met多态性与胃癌化疗反应及预后有关。XRCC3 Thr241Met多态性可能影响亚洲人的胃癌风险。
