五例癫痫患者应用左乙拉西坦出现脱发。
Hair loss with levetiracetam in five patients with epilepsy.
机构信息
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China.
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China.
出版信息
Seizure. 2014 Feb;23(2):158-60. doi: 10.1016/j.seizure.2013.11.007. Epub 2013 Nov 16.
PURPOSE
To report cases of hair loss with levetiracetam (LEV) in epilepsy patient and summarise their demographic and clinical features.
METHOD
All patients reported attended the epilepsy outpatient clinic of the West China Hospital, Sichuan University. Demographic and clinical information was obtained from medical records and by interview. All the patients were under regular follow up.
RESULTS
Five epilepsy patients (4 females and 1 male) are reported. All developed hair loss within two months of starting LEV treatment. Three had idiopathic epilepsy, two symptomatic epilepsy. Three patients received LEV monotherapy, two combination treatment. None decided to switch away from LEV to another drug after developing hair loss, although the dose of LEV was reduced in one patient.
CONCLUSION
Hair loss may be a rare side effect of LEV treatment in patients with epilepsy. LEV-related hair loss appears reversible if the dose is reduced or treatment is stopped.
目的
报告使用左乙拉西坦（LEV）治疗癫痫患者发生脱发的病例，并总结其人口统计学和临床特征。
方法
所有报告的患者均在四川大学华西医院癫痫门诊就诊。从病历和访谈中获取人口统计学和临床信息。所有患者均定期随访。
结果
报告了 5 例癫痫患者（4 名女性和 1 名男性）。所有患者均在开始 LEV 治疗后两个月内出现脱发。3 例为特发性癫痫，2 例为症状性癫痫。3 例患者接受 LEV 单药治疗，2 例联合治疗。尽管 1 名患者减少了 LEV 的剂量，但脱发后均未决定将 LEV 换用其他药物。
结论
脱发可能是癫痫患者使用 LEV 治疗的罕见副作用。如果减少剂量或停止治疗，LEV 相关的脱发似乎是可逆的。
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