Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Int J Radiat Oncol Biol Phys. 2014 Feb 1;88(2):453-8. doi: 10.1016/j.ijrobp.2013.10.024. Epub 2013 Dec 5.
A new system for manufacturing a proton range compensator (RC) was developed by using a 3-dimensional printer (3DP). The physical accuracy and dosimetric characteristics of the new RC manufactured by 3DP (RC_3DP) were compared with those of a conventional RC (RC_CMM) manufactured by a computerized milling machine (CMM).
An RC for brain tumor treatment with a scattered proton beam was calculated with a treatment planning system, and the resulting data were converted into a new format for 3DP using in-house software. The RC_3DP was printed with ultraviolet curable acrylic plastic, and an RC_CMM was milled into polymethylmethacrylate using a CMM. The inner shape of both RCs was scanned by using a 3D scanner and compared with TPS data by applying composite analysis (CA; with 1-mm depth difference and 1 mm distance-to-agreement criteria) to verify their geometric accuracy. The position and distal penumbra of distal dose falloff at the central axis and field width of the dose profile at the midline depth of spread-out Bragg peak were measured for the 2 RCs to evaluate their dosimetric characteristics. Both RCs were imaged on a computed tomography scanner to evaluate uniformity of internal density. The manufacturing times for both RCs were compared to evaluate the production efficiency.
The pass rates for the CA test were 99.5% and 92.5% for RC_3DP and RC_CMM, respectively. There was no significant difference in dosimetric characteristics and uniformity of internal density between the 2 RCs. The net fabrication times of RC_3DP and RC_CMM were about 18 and 3 hours, respectively.
The physical accuracy and dosimetric characteristics of RC_3DP were comparable with those of the conventional RC_CMM, and significant system minimization was provided.
通过使用三维打印机(3DP)开发了一种用于制造质子射程补偿器(RC)的新系统。比较了使用 3DP 制造的新型 RC(RC_3DP)的物理准确性和剂量学特性与使用计算机铣床(CMM)制造的常规 RC(RC_CMM)的物理准确性和剂量学特性。
使用治疗计划系统计算了用于脑肿瘤治疗的散射质子束的 RC,并用内部软件将得到的数据转换为 3DP 的新格式。使用紫外线可固化丙烯酸塑料打印 RC_3DP,使用 CMM 将聚甲基丙烯酸甲酯铣削成 RC_CMM。使用 3D 扫描仪扫描两个 RC 的内部形状,并通过应用复合分析(CA;使用 1mm 深度差和 1mm 一致性标准)将其与 TPS 数据进行比较,以验证其几何精度。测量了两个 RC 在中央轴上的远端剂量下降位置和远端半影以及扩展布拉格峰中线深度处的剂量分布的场宽,以评估其剂量学特性。在 CT 扫描仪上对两个 RC 进行成像,以评估内部密度的均匀性。比较了两个 RC 的制造时间,以评估生产效率。
CA 测试的合格率分别为 RC_3DP 的 99.5%和 RC_CMM 的 92.5%。两个 RC 的剂量学特性和内部密度均匀性没有显著差异。RC_3DP 和 RC_CMM 的净制造时间分别约为 18 小时和 3 小时。
RC_3DP 的物理准确性和剂量学特性与常规 RC_CMM 相当,并且提供了显著的系统简化。