Senba M, Itakura H, Yamashita H, Huang H J
Acta Pathol Jpn. 1986 Sep;36(9):1327-33.
Of the 12 cases, 2 (17%) showed eosinophilic globules in the typical cutaneous type of Kaposi's sarcoma. The globules were stained with periodic acid-Schiff (PAS), periodic acid-Schiff reagent after diastase digestion, and phosphotungstic acid hematoxylin (PTAH), but were not stained with Mayer's mucicarmine, and alcian blue. As the results, these globules might be glycoprotein. The shape of the globules was very similar to glycoprotein globules of yolk sac tumor (endodermal sinus tumor) in the tissue of the ovary and testis. In the yolk sac tumor, similar globules are stained with alpha-fetoprotein, beta-subunit of human chorionic gonadotropin, and alpha-1-antitrypsin using immunohistochemical techniques. Immunoperoxidase investigations were done with antibodies to alpha-fetoprotein, beta-subunit of human chorionic gonadotropin, alpha-1-antitrypsin, and carcinoembryonic antigen in the eosinophilic globules of Kaposi's sarcoma, but these antigens were detected in the globules. The morphogenesis of the glycoprotein globules is not clear yet. A better understanding of the source of globules in Kaposi's sarcoma awaits further research.
在这12例病例中，2例（17%）在典型皮肤型卡波西肉瘤中显示嗜酸性小球。这些小球经高碘酸-希夫（PAS）染色、淀粉酶消化后的高碘酸-希夫试剂染色以及磷钨酸苏木精（PTAH）染色，但不被迈尔氏黏卡红和阿尔辛蓝染色。结果显示，这些小球可能是糖蛋白。小球的形态与卵巢和睾丸组织中卵黄囊瘤（内胚窦瘤）的糖蛋白小球非常相似。在卵黄囊瘤中，使用免疫组织化学技术，类似的小球可被甲胎蛋白、人绒毛膜促性腺激素β亚基和α1抗胰蛋白酶染色。对卡波西肉瘤嗜酸性小球进行了针对甲胎蛋白、人绒毛膜促性腺激素β亚基、α1抗胰蛋白酶和癌胚抗原的免疫过氧化物酶研究，但在小球中未检测到这些抗原。糖蛋白小球的形态发生尚不清楚。对卡波西肉瘤中小球来源的更好理解有待进一步研究。
