根据脑血管风险分层的老年受试者中白质高信号与脑血流的关联
White Matter Hyperintensity Associations with Cerebral Blood Flow in Elderly Subjects Stratified by Cerebrovascular Risk.
作者信息
Bahrani Ahmed A, Powell David K, Yu Guoquiang, Johnson Eleanor S, Jicha Gregory A, Smith Charles D
机构信息
Department of Biomedical Engineering, School of Engineering, University of Kentucky, Lexington, Kentucky; Department of Biomedical Engineering, AL-Khwarizmi College of Engineering, University of Baghdad, Baghdad, Iraq.
Magnetic Resonance Imaging and Spectroscopy Center (MRISC), University of Kentucky, Lexington, Kentucky.
出版信息
J Stroke Cerebrovasc Dis. 2017 Apr;26(4):779-786. doi: 10.1016/j.jstrokecerebrovasdis.2016.10.017. Epub 2017 Jan 4.
OBJECTIVE
This study aims to add clarity to the relationship between deep and periventricular brain white matter hyperintensities (WMHs), cerebral blood flow (CBF), and cerebrovascular risk in older persons.
METHODS
Deep white matter hyperintensity (dWMH) and periventricular white matter hyperintensity (pWMH) and regional gray matter (GM) and white matter (WM) blood flow from arterial spin labeling were quantified from magnetic resonance imaging scans of 26 cognitively normal elderly subjects stratified by cerebrovascular disease (CVD) risk. Fluid-attenuated inversion recovery images were acquired using a high-resolution 3-dimensional (3-D) sequence that reduced partial volume effects seen with slice-based techniques.
RESULTS
dWMHs but not pWMHs were increased in patients at high risk of CVD; pWMHs but not dWMHs were associated with decreased regional cortical (GM) blood flow. We also found that blood flow in WM is decreased in regions of both pWMH and dWMH, with a greater degree of decrease in pWMH areas.
CONCLUSIONS
WMHs are usefully divided into dWMH and pWMH regions because they demonstrate differential effects. 3-D regional WMH volume is a potentially valuable marker for CVD based on associations with cortical CBF and WM CBF.
目的
本研究旨在进一步明确老年人深部及脑室周围脑白质高信号（WMHs）、脑血流量（CBF）与脑血管风险之间的关系。
方法
对26名认知正常的老年受试者进行磁共振成像扫描，根据脑血管疾病（CVD）风险进行分层，通过动脉自旋标记技术对深部白质高信号（dWMH）、脑室周围白质高信号（pWMH）以及区域灰质（GM）和白质（WM）血流量进行量化。使用高分辨率三维（3-D）序列采集液体衰减反转恢复图像，该序列减少了基于切片技术所见的部分容积效应。
结果
CVD高风险患者的dWMHs增加，而pWMHs未增加；pWMHs而非dWMHs与区域皮质（GM）血流量减少相关。我们还发现，pWMH和dWMH区域的WM血流量均减少，pWMH区域的减少程度更大。
结论
WMHs可有效分为dWMH和pWMH区域，因为它们表现出不同的影响。基于与皮质CBF和WM CBF的关联，3-D区域WMH体积是CVD的一个潜在有价值的标志物。
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