Faculty of Health Management, Guangzhou Medical University, Guangzhou, China; Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Guangzhou Psychiatric Hospital, Guangzhou, China.
Guangzhou Psychiatric Hospital, Guangzhou, China.
Neuropsychologia. 2014 Jan;53:213-20. doi: 10.1016/j.neuropsychologia.2013.11.023. Epub 2013 Dec 4.
Anhedonia is associated with reward-processing deficits of the dopamine system, which may increase the risk of depression. Nevertheless, few previous studies have examined the influence of hedonic tone on event-related potential (ERP) measures of reward processing in major depressive disorder. A simple gambling task was used to elicit feedback negativity (FN), an ERP component elicited by feedback indicating gain versus loss, in 27 patients with major depression and 27 healthy participants. We found that participants with depression were characterized by reduced FN responses, especially towards monetary gains, but not losses, compared with healthy individuals. In addition, the amplitude of FN to gain feedback in participants with depression was related to anhedonia severity and depressive symptoms. These findings indicate an association between low hedonic capacity and reduction in FN. As a neural measure of reward sensitivity, FN may be generated in part by reward-related activity.
快感缺失与多巴胺系统的奖赏加工缺陷有关，这可能会增加患抑郁症的风险。然而，以前很少有研究检查愉悦音调对重性抑郁障碍中与奖赏加工相关的事件相关电位（ERP）测量的影响。使用简单的赌博任务诱发反馈负波（FN），这是一种由表示收益与损失的反馈引起的 ERP 成分，在 27 名重性抑郁障碍患者和 27 名健康参与者中进行了研究。我们发现，与健康个体相比，抑郁患者的 FN 反应减少，尤其是在获得金钱奖励时，但在损失时则没有。此外，FN 对收益反馈的幅度与快感缺失的严重程度和抑郁症状有关。这些发现表明，低愉悦能力与 FN 减少之间存在关联。作为奖赏敏感性的神经测量，FN 可能部分由与奖赏相关的活动产生。
