Eusebi V, Lamovec J, Cattani M G, Fedeli F, Millis R R
Am J Surg Pathol. 1986 Dec;10(12):855-61. doi: 10.1097/00000478-198612000-00004.
Three cases of acantholytic squamous-cell carcinoma of the breast are reported. They all had histological features resembling those of angiosarcoma or adenocarcinoma. They were not angiosarcoma, since in all three cases areas of squamous differentiation were present; in addition, the neoplastic cells were negative when stained for factor VIII, but were positive with anti-epidermal keratin. The glandular pattern exhibited, especially in Case 2, was difficult to differentiate from that of an ordinary carcinoma. However, the presence of dyskeratotic cells within the lumina, and the absence of alcian blue/periodic acid-Schiff positive material, and epithelial membrane antigen staining, were evidence against the diagnosis of adenocarcinoma. The patients died 5, 6, and 16 months after the diagnosis. Tumors with these histological features may have a very aggressive clinical course.
本文报告了3例乳腺棘层松解性鳞状细胞癌。它们均具有类似于血管肉瘤或腺癌的组织学特征。它们并非血管肉瘤，因为在所有3例中均存在鳞状分化区域；此外，肿瘤细胞因子Ⅷ染色为阴性，但抗表皮角蛋白染色呈阳性。尤其是病例2中呈现的腺管样结构，很难与普通癌相鉴别。然而，管腔内存在角化不良细胞，且缺乏阿尔辛蓝/过碘酸希夫阳性物质以及上皮膜抗原染色，这些均不支持腺癌的诊断。患者在确诊后5、6和16个月死亡。具有这些组织学特征的肿瘤可能具有非常侵袭性的临床病程。
