Zidar N, Gale N, Zupevc A, Dovsak D
Medical Faculty, Institute of Pathology, Ljubljana, Slovenia.
J Clin Pathol. 2006 Nov;59(11):1206-8. doi: 10.1136/jcp.2005.029553.
Informed consent was obtained for the publication of the patients' details in this report. Two cases of pseudovascular adenoid squamous-cell carcinoma (SCC) in the oral cavity are described, which were characterised by acantholysis of the tumour cells, with formation of anastomosing spaces and channels mimicking an angiosarcoma. Both tumours contained foci of SCC suggesting the correct diagnosis: in one patient conventional SCC, and in the other, a spindle-cell carcinoma. The pathogenesis of pseudovascular adenoid SCC is unknown. Our cases were characterised by loss of immunohistochemical expression of E-cadherin, one of the major adhesion molecules of epithelial cells. Pseudovascular adenoid SCC is suggested to be pathogenetically related to the loss of E-cadherin expression, leading to the loss of tumour cell-cell adhesion.
已获得患者同意在本报告中公布其详细信息。本文描述了两例口腔假性血管腺样鳞状细胞癌（SCC），其特征为肿瘤细胞棘层松解，形成相互吻合的腔隙和通道，类似血管肉瘤。两例肿瘤均含有SCC灶，提示正确诊断：1例为传统型SCC，另1例为梭形细胞癌。假性血管腺样SCC的发病机制尚不清楚。我们的病例特征为上皮细胞主要黏附分子之一E-钙黏蛋白免疫组化表达缺失。假性血管腺样SCC被认为在发病机制上与E-钙黏蛋白表达缺失有关，导致肿瘤细胞间黏附丧失。
