School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, China.
The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230032, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Mar 25;122:193-7. doi: 10.1016/j.saa.2013.11.049. Epub 2013 Nov 20.
The incidence and mortality of lung cancer remains so high that it is very urgent to develop an effective method for early detection of lung cancer. Serum can reflect physiological and pathological changes of human body, so FTIR spectroscopy was used to compare lung cancer patients' and healthy persons' serum in this study. The A1080/A1170 ratio might be potentially useful for distinguishing lung cancer patients' serum from healthy persons' serum. Moreover, the result of curve fitting indicated that the ratios of α-helix/antiparallel β-sheet were lower for lung cancer patients' serum than those for healthy persons' serum. These results indicated that IR spectra of serum might be potentially useful for detecting lung cancer.
肺癌的发病率和死亡率仍然很高，因此非常有必要开发一种有效的肺癌早期检测方法。血清可以反映人体的生理和病理变化，因此本研究采用傅里叶变换红外（FTIR）光谱法比较了肺癌患者和健康人的血清。A1080/A1170 比值可能有助于区分肺癌患者的血清和健康人的血清。此外，曲线拟合的结果表明，肺癌患者血清的α-螺旋/反平行β-折叠比值低于健康人血清。这些结果表明，血清的红外光谱可能有助于检测肺癌。
