School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China; The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230032, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2013 Dec;116:365-9. doi: 10.1016/j.saa.2013.07.055. Epub 2013 Aug 3.
Since serum can reflect human beings' physiological and pathological conditions, FTIR spectroscopy was used to compare gastric cancer patients' serum with healthy persons' serum in this study. The H2959/H2931, H1646/H1550, H1314/H1243, H1453/H1400 and H1080/H1550 ratios were calculated, among these ratios, the H2959/H2931 ratio might be a standard for distinguishing gastric cancer patients from healthy persons. Then curve fitting was processed using Gaussian curves in the 1140-1000 cm(-1) region, and the result showed that the RNA/DNA ratios of gastric cancer patients' serum were obviously lower than those of healthy persons' serum. The results suggest that FTIR spectroscopy may be a potentially useful tool for diagnosis of gastric cancer.
由于血清可以反映人体的生理和病理状况，因此本研究使用傅里叶变换红外（FTIR）光谱比较了胃癌患者和健康人的血清。计算了 H2959/H2931、H1646/H1550、H1314/H1243、H1453/H1400 和 H1080/H1550 比值，其中 H2959/H2931 比值可能是区分胃癌患者和健康人的标准。然后在 1140-1000 cm(-1) 区域使用高斯曲线进行曲线拟合，结果表明胃癌患者血清的 RNA/DNA 比值明显低于健康人血清。这些结果表明 FTIR 光谱可能是一种用于诊断胃癌的潜在有用工具。
