用于活细胞成像的小胶质细胞特异性荧光探针。
Microglia specific fluorescent probes for live cell imaging.
作者信息
Leong Cheryl, Lee Sung Chan, Ock Jiyeon, Li Xin, See Peter, Park Sung Jin, Ginhoux Florent, Yun Seong-Wook, Chang Young-Tae
机构信息
NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.
出版信息
Chem Commun (Camb). 2014 Feb 4;50(9):1089-91. doi: 10.1039/c3cc45715j.
PMID:24316694
Abstract
Small molecule fluorescent probes offer significant advantages over conventional antibody and fluorescent protein labeling techniques. Here we present and , dyes that label live microglia specifically. They may be applied to the isolation and imaging of live microglia when investigating their role in neuroinflammatory diseases.
摘要
小分子荧光探针相对于传统的抗体和荧光蛋白标记技术具有显著优势。在此，我们展示了两种染料，它们能够特异性地标记活的小胶质细胞。在研究小胶质细胞在神经炎症性疾病中的作用时，它们可用于活小胶质细胞的分离和成像。
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