大鼠腹膜肥大细胞释放二肽基肽酶II。
Rat peritoneal mast cells release dipeptidyl peptidase II.
作者信息
Struckhoff G, Heymann E
出版信息
Biochem J. 1986 May 15;236(1):215-9. doi: 10.1042/bj2360215.
Abstract
Purified rat peritoneal mast cells have a 10-20-fold higher dipeptidyl peptidase II (DPP II) activity as compared with that of macrophages from the same source. Upon stimulation with the secretagogue Compound 48/80, DPP II is released from peritoneal-lavage cells and from purified mast cells, but not from purified macrophages, in a dose-dependent manner. Maximally, about one-third of the DPP II present in peritoneal-lavage cells is released. Substance P and the antigen/IgE system probably produce a similar effect. Both histamine and Zn2+, two ingredients of mast-cell granules, strongly inhibit DPP II at concentrations reported to occur in the granules. A possible role of mast-cell DPP II in the remodelling of connective tissue is discussed.
摘要
与来自相同来源的巨噬细胞相比，纯化的大鼠腹膜肥大细胞的二肽基肽酶II（DPP II）活性高10 - 20倍。用促分泌剂化合物48/80刺激后，DPP II以剂量依赖性方式从腹腔灌洗细胞和纯化的肥大细胞中释放出来，但不从纯化的巨噬细胞中释放。腹腔灌洗细胞中存在的DPP II最多约有三分之一被释放。P物质和抗原/IgE系统可能产生类似的作用。组胺和Zn2+这两种肥大细胞颗粒成分，在据报道颗粒中存在的浓度下能强烈抑制DPP II。本文讨论了肥大细胞DPP II在结缔组织重塑中的可能作用。
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