药物基因组学检测与个体化治疗的前景。

Pharmacogenomic testing and the prospect of individualized treatment.

作者信息

Jonas Daniel E, Wines Roberta

机构信息

Department of Medicine, University of North Carolina School of Medicine; Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina Eshelman School Of Pharmacy; and Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, 5034 Old Clinic Bldg., CB 7110, Chapel Hill, NC 27599, USA.

出版信息

N C Med J. 2013 Nov-Dec;74(6):485-93.

PMID:24316770

Abstract

Pharmacogenomics offers the hope of greater individualization of treatment. Therapies that exemplify the promise of pharmacogenomics include anticoagulation with warfarin and the use of antiplatelet medications (eg, clopidogrel) for secondary prevention after acute coronary syndrome. Good evidence of clinical utility must be obtained before pharmacogenomic testing is widely implemented.

摘要

药物基因组学为实现更个性化的治疗带来了希望。体现药物基因组学前景的疗法包括使用华法林进行抗凝治疗，以及在急性冠状动脉综合征后使用抗血小板药物（如氯吡格雷）进行二级预防。在广泛开展药物基因组检测之前，必须获得其临床效用的充分证据。