Division of Endocrinology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
J Endocrinol Invest. 2013 Nov;36(10):889-95. doi: 10.1007/BF03346759.
MicroRNAs (miRNAs) are small non-coding RNA molecules that represent a major class of molecular regulators. miRNAs have been implicated in the pathogenesis of several human tumors, including pituitary adenomas. Altered expression of miRNAs has been described in pituitary adenomas, and specific miRNA signatures are related to clinical and therapeutic characteristics of the tumors. The data suggest that miRNAs influence various genes known to be associated with the pathogenesis of pituitary adenomas and in this review we summarize these currently available studies focusing on miRNAs in pituitary adenomas.
MicroRNAs (miRNAs) 是一类小的非编码 RNA 分子，它们是主要的分子调控因子之一。miRNAs 参与了多种人类肿瘤的发病机制，包括垂体腺瘤。已经描述了 miRNA 在垂体腺瘤中的表达改变，并且特定的 miRNA 特征与肿瘤的临床和治疗特征相关。这些数据表明，miRNAs 影响各种已知与垂体腺瘤发病机制相关的基因，在这篇综述中，我们总结了目前关于垂体腺瘤中 miRNA 的这些研究。
