Németh Kinga, Darvasi Ottó, Szücs Nikolette, Czirják Sándor, Butz Henriett
II. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest.
"Lendület" Örökletes Endokrin Daganatok Kutatócsoport, Magyar Tudományos Akadémia-Semmelweis Egyetem Budapest, Szentkirályi u. 46., 1088.
Orv Hetil. 2018 Feb;159(7):252-259. doi: 10.1556/650.2018.30922.
MicroRNAs (miRNAs) are short, single stranded RNA molecules which play regulatory roles through posttranscriptional regulation of their target genes. Based on our current knowledge, more than 30% of the human protein-coding genes are regulated by miRNAs, hence influencing basic cellular mechanisms including cell proliferation, differentiation and cell death. Differential miRNA expression pattern has been detected in many different types of tumors and, recently, several publications have referred to miRNAs as potential therapeutic targets. Through adjustment of miRNA levels by artificial miRNAs administration or miRNA inhibition, we can influence not only one target gene but also complex biological pathways. Pituitary adenoma is the second most frequent intracranial tumor. In spite of this, the molecular mechanism of the pituitary adenoma formation is not yet entirely revealed. Recently, more and more evidences have been found suggesting that miRNAs have an important role in pituitary adenoma pathogenesis. Here, we summarize the recent results related to this role and highlight the therapeutic potentials in pituitary adenomas. Orv Hetil. 2018; 159(7): 252-259.
微小RNA（miRNA）是短的单链RNA分子，通过对其靶基因进行转录后调控发挥调节作用。根据我们目前的知识，超过30%的人类蛋白质编码基因受miRNA调控，从而影响包括细胞增殖、分化和细胞死亡在内的基本细胞机制。在许多不同类型的肿瘤中都检测到了差异miRNA表达模式，最近，有几篇出版物将miRNA称为潜在的治疗靶点。通过人工施用miRNA或抑制miRNA来调节miRNA水平，我们不仅可以影响一个靶基因，还可以影响复杂的生物学途径。垂体腺瘤是第二常见的颅内肿瘤。尽管如此，垂体腺瘤形成的分子机制尚未完全揭示。最近，越来越多的证据表明miRNA在垂体腺瘤发病机制中起重要作用。在此，我们总结了与此作用相关的最新结果，并强调了垂体腺瘤的治疗潜力。《匈牙利医学周报》。2018年；159(7):252 - 259。
