Shafie Nurul Husna, Esa Norhaizan Mohd, Ithnin Hairuszah, Saad Norazalina, Pandurangan Ashok Kumar
Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Int J Mol Sci. 2013 Dec 2;14(12):23545-58. doi: 10.3390/ijms141223545.
Inositol hexaphosphate (IP6), or phytic acid is a natural dietary ingredient and has been described as a "natural cancer fighter", being an essential component of nutritional diets. The marked anti-cancer effect of IP6 has resulted in our quest for an understanding of its mechanism of action. In particular, our data provided strong evidence for the induction of apoptotic cell death, which may be attributable to the up-regulation of Bax and down-regulation of Bcl-xl in favor of apoptosis. In addition, the up-regulation of caspase-3 and -8 expression and activation of both caspases may also contribute to the apoptotic cell death of human colorectal adenocarcinoma HT-29 cells when exposed to IP6. Collectively, this present study has shown that rice bran IP6 induces apoptosis, by regulating the pro- and anti-apoptotic markers; Bax and Bcl-xl and via the activation of caspase molecules (caspase-3 and -8).
肌醇六磷酸（IP6），即植酸，是一种天然的膳食成分，被称为“天然抗癌剂”，是营养饮食的重要组成部分。IP6显著的抗癌作用促使我们去了解其作用机制。特别是，我们的数据为诱导凋亡性细胞死亡提供了有力证据，这可能归因于Bax的上调和Bcl-xl的下调，从而有利于细胞凋亡。此外，当人结肠腺癌HT-29细胞暴露于IP6时，caspase-3和-8表达的上调以及这两种半胱天冬酶的激活也可能导致细胞凋亡性死亡。总的来说，本研究表明米糠IP6通过调节促凋亡和抗凋亡标志物Bax和Bcl-xl，并通过激活半胱天冬酶分子（caspase-3和-8）来诱导细胞凋亡。
