G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Prospect 100 let Vladivostoku, 159, Vladivostok 690022, Russia.
Mar Drugs. 2013 Dec 2;11(12):4876-901. doi: 10.3390/md11124876.
Many marine-derived polysaccharides and their analogues have been reported as showing anticancer and cancer preventive properties. These compounds demonstrate interesting activities and special modes of action, differing from each other in both structure and toxicity profile. Herein, literature data concerning anticancer and cancer preventive marine polysaccharides are reviewed. The structural diversity, the biological activities, and the molecular mechanisms of their action are discussed.
许多海洋来源的多糖及其类似物已被报道具有抗癌和防癌特性。这些化合物表现出有趣的活性和特殊的作用模式,在结构和毒性特征上彼此不同。本文综述了有关抗癌和防癌海洋多糖的文献数据。讨论了它们的结构多样性、生物活性和作用的分子机制。