在阿尔茨海默病风险患者出现认知症状之前，影像学标记可预测大脑结构和功能的变化。
Imaging markers of structural and functional brain changes that precede cognitive symptoms in risk for Alzheimer's disease.
机构信息
Center for Cognitive Neurosciences, Semel Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, 90095, USA,
出版信息
Brain Imaging Behav. 2014 Jun;8(2):251-61. doi: 10.1007/s11682-013-9278-4.
Abstract
Neuroimaging has rapidly advanced investigations into dysfunction both within and emanating from the hippocampus in early Alzheimer's disease . Focusing on prodromal subjects, we will discuss structural changes to hippocampal subregions, alterations to functional activity both within the hippocampus and elsewhere in the cortex, as well as changes to structural white matter connectivity and changes to functionally correlated patterns during memory performance. We present ample evidence that asymptomatic subjects demonstrate substantial identifiable brain changes before the onset of cognitive decline, but suggest there is significant work yet to be accomplished before applying these findings to individual patients.
摘要
神经影像学技术的快速发展推动了对早期阿尔茨海默病中海马内部和海马发出的功能障碍的研究。本文将重点讨论前驱期患者的海马亚区结构变化、海马内部和皮质其他区域功能活动的改变、结构白质连接的改变以及记忆表现时功能相关模式的改变。我们充分证明了无症状患者在认知能力下降之前就已经出现了大量可识别的大脑变化，但我们也认为，在将这些发现应用于个体患者之前，还有大量工作需要完成。
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1
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J Neurosci. 2013 Aug 28;33(35):14184-92. doi: 10.1523/JNEUROSCI.1987-13.2013.
2
Common variants in psychiatric risk genes predict brain structure at birth.常见的精神疾病风险基因变异可预测出生时的大脑结构。
Cereb Cortex. 2014 May;24(5):1230-46. doi: 10.1093/cercor/bhs401. Epub 2013 Jan 2.
3
Genetics of familial and sporadic Alzheimer's disease.家族性和散发性阿尔茨海默病的遗传学
Front Biosci (Elite Ed). 2013 Jan 1;5(1):167-77. doi: 10.2741/e605.
4
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Ann Neurol. 2012 Oct;72(4):571-7. doi: 10.1002/ana.23643.
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Prediction of Alzheimer's disease in subjects with mild cognitive impairment from the ADNI cohort using patterns of cortical thinning.利用皮质变薄模式预测 ADNI 队列中轻度认知障碍患者的阿尔茨海默病。
Neuroimage. 2013 Jan 15;65:511-21. doi: 10.1016/j.neuroimage.2012.09.058. Epub 2012 Oct 2.
6
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9
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J Neurosci. 2012 Jun 13;32(24):8254-62. doi: 10.1523/JNEUROSCI.0305-12.2012.
10
Disrupted functional brain connectome in individuals at risk for Alzheimer's disease.阿尔茨海默病高危个体的功能脑连接组紊乱。
Biol Psychiatry. 2013 Mar 1;73(5):472-81. doi: 10.1016/j.biopsych.2012.03.026. Epub 2012 Apr 25.
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