Kinesiology Program, The University of Guelph-Humber, Room GH-308-G, 207 Humber College Boulevard, Toronto, ON, Canada, M9W 5L7,
J Cancer Surviv. 2014 Jun;8(2):190-8. doi: 10.1007/s11764-013-0329-z. Epub 2013 Dec 7.
Recent literature has shown that preoperative physical activity (PA) can positively influence surgical outcomes. It is unknown whether the effect of meeting PA guidelines for cancer survivors can impact quality of life following radical prostatectomy for prostate cancer.
We reviewed our institutional database of prostate cancer outcomes and included patients that underwent radical prostatectomy and completed the Godin-Shephard Leisure Time Exercise Questionnaire (GLTEQ), the Patient-Oriented Prostate Utility Scale (PORPUS), the International Prostate Symptom Score (IPSS), and the five-item International Index of Erectile Function (IIEF). Participants were categorized as meeting or not meeting the American College of Sports Medicine physical activity guidelines for cancer survivors (150 min of moderate intensity or 75 min of vigorous intensity PA per week). Radical prostatectomy outcomes were measured preoperatively and at 6 and 26-weeks postoperatively.
From June 2008 to August 2012, 509 men underwent curative, nerve-sparing radical prostatectomy for prostate cancer and completed the GLTEQ, of whom 46% met the PA guidelines. Prior to surgery, men that met the PA guidelines reported higher quality of life (p < 0.001) and erectile function (p = 0.049) than men that did not meet the guidelines. Quality of life at all postoperative timepoints was higher for men that met the PA guidelines after adjusting for age, preoperative body mass index, and surgical approach (p = 0.02). Men that met the PA guidelines were 19% less likely to be incontinent at 6 weeks postoperatively (p = 0.028).
PA volume may be a useful marker at predicting postoperative recovery of quality of life and urinary incontinence following radical prostatectomy.
Cancer survivors should be encouraged to meet PA guidelines prior to surgery in an effort to attenuate the decline in HRQOL and facilitate recovery.
最近的文献表明，术前体力活动（PA）可以积极影响手术结果。目前尚不清楚满足癌症幸存者 PA 指南是否会影响前列腺癌根治性前列腺切除术后的生活质量。
我们回顾了我们机构的前列腺癌结局数据库，并纳入了接受根治性前列腺切除术且完成了 Godin-Shephard 休闲时间运动问卷（GLTEQ）、患者导向前列腺效用量表（PORPUS）、国际前列腺症状评分（IPSS）和五分量表国际勃起功能指数（IIEF）的患者。参与者分为符合或不符合美国运动医学学院癌症幸存者体力活动指南（每周 150 分钟中等强度或 75 分钟剧烈强度 PA）。在术前、术后 6 周和 26 周测量根治性前列腺切除术的结果。
从 2008 年 6 月至 2012 年 8 月，509 名男性接受了根治性、神经保留性前列腺癌根治术，并完成了 GLTEQ，其中 46%的人符合 PA 指南。在手术前，符合 PA 指南的男性报告生活质量（p<0.001）和勃起功能（p=0.049）更高，而不符合指南的男性则更低。在调整年龄、术前体重指数和手术方式后，符合 PA 指南的男性在所有术后时间点的生活质量更高（p=0.02）。在术后 6 周时，符合 PA 指南的男性尿失禁的可能性降低 19%（p=0.028）。
PA 量可能是预测根治性前列腺切除术后生活质量和尿失禁恢复的有用指标。
应鼓励癌症幸存者在手术前达到 PA 指南，以减轻 HRQOL 的下降并促进恢复。
