Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Parasitol Res. 2014 Mar;113(3):829-35. doi: 10.1007/s00436-013-3713-8. Epub 2013 Dec 7.
Worldwide, the highest incidence of cholangiocarcinoma (CCA) is found in northeast Thailand, the endemic area of Opisthorchis viverrini infection. Cumulated clinical data revealed that the majority of CCA patients are men. However, many other types of cancers are more commonly found in women. In this study, we investigated the sex differences in the development of CCA, induced by O. viverrini infection and N-nitrosodimethylamine administration, in Syrian hamsters. Histopathology, liver function tests, and fecal egg counts were analyzed. The results showed that there are no sex differences in hamsters responses to O. viverrini infection and no prevalence of CCA development. Even though serum ALT level in O. viverrini-infected or CCA hamsters was significantly increased in female compared to male (p < 0.05) and uninfected control (p < 0.05), our results may imply that the higher prevalence of opisthorchiasis and CCA in men than in women in northeast Thailand may depend on behaviors of an individual exposed to risk factors rather than gender difference.
在全球范围内，胆管癌（CCA）的发病率最高的地区是泰国东北部，该地区是华支睾吸虫感染的流行区。累积的临床数据显示，大多数 CCA 患者为男性。然而，许多其他类型的癌症在女性中更为常见。在这项研究中，我们研究了华支睾吸虫感染和 N-亚硝基二甲胺给药诱导的 CCA 在叙利亚仓鼠中的性别差异。分析了组织病理学、肝功能试验和粪便虫卵计数。结果表明，华支睾吸虫感染后仓鼠的反应没有性别差异，也没有 CCA 发展的流行。尽管与男性相比，感染华支睾吸虫或 CCA 的仓鼠的血清 ALT 水平在女性中显著升高（p<0.05），与未感染的对照组相比（p<0.05），但我们的结果可能表明，泰国东北部男性比女性更普遍患有华支睾吸虫病和 CCA，这可能取决于接触危险因素的个体的行为，而不是性别差异。
