Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX.
Am J Phys Anthropol. 2014 Jan;153(1):9-14. doi: 10.1002/ajpa.22357. Epub 2013 Nov 6.
Baboons (Papio hamadryas sp.) exhibit significant sexual dimorphism in body size. Sexual dimorphism is also exhibited in a number of circulating factors associated with risk of cardiometabolic disease. We investigated whether sexual dimorphism in body size and composition underlie these differences. We examined data from 28 male and 24 female outdoor group-housed young adult baboons enrolled in a longitudinal observational study of cardiometabolic disease risk factors. Animals were sedated with ketamine HCl (10 mg/kg) before undergoing venous blood draws, basic body measurements, and dual-energy X-ray absorptiometry body composition scans. Percentage glycated hemoglobin A1c (%HbA1c ) was measured in whole blood. Serum samples were analyzed for glucose, insulin, C-peptide, high-density lipoprotein, and triglyceride concentrations. Males were heavier and had greater body length and lean tissue mass than females. Females had a greater body fat percentage relative to males (10.8 ± 6.4 vs. 6.9 ± 4.0, P = 0.01). Although C-peptide, fasting glucose, and %HbA1c did not differ between the sexes, females had greater fasting insulin and triglyceride compared to their male counterparts. Insulin and percentage body fat were significantly correlated in males (r = 0.61, P = 0.001) and to a lesser extent in females (r = 0.43, P = 0.04). Overall, relations between adiposity and fasting insulin and fasting triglyceride were stronger in males. After accounting for differences in percentage body fat, fasting insulin and triglyceride were no longer statistically different between males and females. Despite stronger correlations between relative adiposity and insulin and triglyceride in males, the higher fasting insulin and triglyceride of female baboons may be underlain by their greater relative body fat masses.
狒狒（Papio hamadryas sp.）在体型上表现出显著的性别二态性。许多与心血管代谢疾病风险相关的循环因子也表现出性别二态性。我们研究了体型和成分的性别二态性是否是这些差异的基础。我们检查了 28 只雄性和 24 只雌性户外群居的年轻成年狒狒的数据，这些狒狒参加了一项关于心血管代谢疾病风险因素的纵向观察研究。动物在接受静脉采血、基本身体测量和双能 X 射线吸收法身体成分扫描前用盐酸氯胺酮（10mg/kg）镇静。全血中测量糖化血红蛋白 A1c 的百分比（%HbA1c）。分析血清样本中的葡萄糖、胰岛素、C 肽、高密度脂蛋白和甘油三酯浓度。雄性比雌性更重，体长和瘦体重更大。与雄性相比，雌性的体脂肪百分比更大（10.8±6.4%比 6.9±4.0%，P=0.01）。尽管雌雄两性之间的 C 肽、空腹血糖和%HbA1c 没有差异，但女性的空腹胰岛素和甘油三酯高于男性。男性的胰岛素和体脂肪百分比呈显著相关（r=0.61，P=0.001），而女性的相关性较弱（r=0.43，P=0.04）。总的来说，在男性中，体脂与空腹胰岛素和空腹甘油三酯之间的关系更强。在考虑了体脂肪百分比的差异后，雄性和雌性之间的空腹胰岛素和甘油三酯不再有统计学差异。尽管男性的相对肥胖程度与胰岛素和甘油三酯之间的相关性更强，但雌性狒狒的空腹胰岛素和甘油三酯较高可能是由于其相对较大的体脂肪量所致。
