Department of Medicine, Vanderbilt University, Nashville, TN, USA.
Wiley Interdiscip Rev Syst Biol Med. 2014 Mar-Apr;6(2):125-35. doi: 10.1002/wsbm.1255. Epub 2013 Dec 6.
Many genetic variants have been shown to affect drug response through changes in drug efficacy and likelihood of adverse effects. Much of pharmacogenomic science has focused on discovering and clinically implementing single gene variants with large effect sizes. Given the increasing complexities of drug responses and their variability, a systems approach may be enabling for discovery of new biology in this area. Further, systems approaches may be useful in addressing challenges in moving these data to clinical implementation, including creation of predictive models of drug response phenotypes, improved clinical decision-making through complex biological models, improving strategies for integrating genomics into clinical practice, and evaluating the impact of implementation programs on public health.
许多遗传变异已被证明会通过改变药物疗效和不良反应的可能性来影响药物反应。 药物基因组学的大部分研究都集中在发现和临床实施具有较大效应的单基因变异上。 鉴于药物反应及其变异性日益复杂，系统方法可能有助于在该领域发现新的生物学。 此外，系统方法可能有助于解决将这些数据转化为临床应用的挑战，包括创建药物反应表型的预测模型，通过复杂的生物学模型改善临床决策，改进将基因组学纳入临床实践的策略以及评估实施计划对公共卫生的影响。
