Department of Medicine, The University of Chicago, Chicago, Illinois, USA.
Clin Pharmacol Ther. 2012 Oct;92(4):446-9. doi: 10.1038/clpt.2012.117. Epub 2012 Aug 29.
The paradigm of individualized drug therapy based on genetics is an ideal that is now potentially possible. However, translation of pharmacogenomics into practice has encountered barriers such as limited availability and the high cost of genetic testing, the delays involved, disagreements about interpretation of results, and even lack of understanding about pharmacogenomics in general. We describe our institutional pharmacogenomics-implementation project, "The 1200 Patients Project," a model designed to overcome these barriers and facilitate the availability of pharmacogenomic information for personalized prescribing.
基于遗传学的个体化药物治疗模式是一种理想，现在已经具有实现的可能性。然而，药物基因组学向实践的转化遇到了一些障碍，如遗传检测的可及性有限且费用高昂、检测过程耗时、对结果的解读存在分歧，甚至对药物基因组学缺乏了解等。我们介绍了本机构的药物基因组学实施项目，即“1200 名患者项目”，该模型旨在克服这些障碍，为个体化用药提供药物基因组学信息。
