Metitieri Tiziana, Barba Carmen, Pellacani Simona, Viggiano Maria Pia, Guerrini Renzo
Pediatric Neurology Unit, Children's Hospital A. Meyer, University of Florence, Viale Pieraccini 24, 50139 Firenze, Italy.
Neural Plast. 2013;2013:306432. doi: 10.1155/2013/306432. Epub 2013 Nov 10.
There are few reports about the effects of perinatal acquired brain lesions on the development of visual perception. These studies demonstrate nonseverely impaired visual-spatial abilities and preserved visual memory. Longitudinal data analyzing the effects of compromised perceptions on long-term visual knowledge in agnosics are limited to lesions having occurred in adulthood. The study of children with focal lesions of the visual pathways provides a unique opportunity to assess the development of visual memory when perceptual input is degraded. We assessed visual recognition and visual memory in three children with lesions to the visual cortex having occurred in early infancy. We then explored the time course of visual memory impairment in two of them at 2 years and 3.7 years from the initial assessment. All children exhibited apperceptive visual agnosia and visual memory impairment. We observed a longitudinal improvement of visual memory modulated by the structural properties of objects. Our findings indicate that processing of degraded perceptions from birth results in impoverished memories. The dynamic interaction between perception and memory during development might modulate the long-term construction of visual representations, resulting in less severe impairment.
关于围产期获得性脑损伤对视觉感知发育影响的报道较少。这些研究表明视觉空间能力未受到严重损害且视觉记忆得以保留。分析知觉受损对失认症患者长期视觉知识影响的纵向数据仅限于成年期发生的损伤。对视路局灶性病变儿童的研究为评估知觉输入退化时视觉记忆的发育提供了独特机会。我们评估了三名婴儿早期发生视觉皮层损伤的儿童的视觉识别和视觉记忆。然后，我们在其中两名儿童初次评估后的2年和3.7年时探究了视觉记忆损害的时间进程。所有儿童均表现出知觉性视觉失认和视觉记忆损害。我们观察到视觉记忆随着物体结构特性的变化而纵向改善。我们的研究结果表明，出生时知觉退化的处理会导致记忆贫乏。发育过程中感知与记忆之间的动态相互作用可能会调节视觉表征的长期构建，从而减轻损害的严重程度。
