基于 iPSC 的细胞治疗：向前迈出的重要一步。
iPSC-Based cell therapy: an important step forward.
机构信息
Director, NIH Center for Regenerative Medicine, 50 South Drive, Bethesda, MD 20892 USA.
出版信息
Stem Cell Reports. 2013 Oct 15;1(4):281-2. doi: 10.1016/j.stemcr.2013.10.002. eCollection 2013.
Abstract
Morizane et al. (2013) show that donor-matched differentiated derivatives of induced pluripotent stem cells (iPSC) do not cause an immune response after transplantation, whereas transplantation of HLA-mismatched iPSC derivatives to the same site clearly does. The importance of these results is discussed in this commentary as we assess how best to move forward with iPSC-based cell therapy.
摘要
森谷等（2013）的研究表明，在移植后，与供体匹配的诱导多能干细胞（iPSC）分化衍生物不会引起免疫反应，而将 HLA 不匹配的 iPSC 衍生物移植到同一部位则会引起明显的免疫反应。在评估如何最好地推进基于 iPSC 的细胞治疗时，我们对这些结果的重要性进行了讨论。
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