基质金属蛋白酶及其抑制剂在感染甲型H5N1 A/鹅/克拉斯诺亚尔斯克oye/627/05病毒的小鼠早期肺纤维化发展中的作用
Role of matrix metalloproteinases and their inhibitor in the development of early pulmonary fibrosis in mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus.
作者信息
Anikina A G, Potapova O V, Shkurupii V A, Shestopalov A M
机构信息
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk; Vector State Research Center of Virology and Biotechnology, Novosibirsk Region, Koltsovo; Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Russia.
出版信息
Bull Exp Biol Med. 2013 Nov;156(1):11-4. doi: 10.1007/s10517-013-2265-3.
High levels of macrophages and fibroblasts expressing MMP-2, MMP-9, and MMP-10 against the background of progressing early fibrosis of the lungs (manifesting in an increase in volume density of type I, III, IV, and VI collagens) were found in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. Progressing fibrosis of the lungs in infected mice was associated with imbalance of collagen synthesis and degradation processes conjugated with high levels of macrophages and fibroblasts expressing TIMP-2.
在感染甲型H5N1 A/鹅/克拉斯诺奥泽尔斯克oye/627/05病毒的C57Bl/6小鼠中，发现高水平的巨噬细胞和成纤维细胞表达MMP - 2、MMP - 9和MMP - 10，同时伴有肺部早期纤维化进展（表现为I、III、IV和VI型胶原的体积密度增加）。感染小鼠肺部纤维化进展与胶原合成和降解过程失衡有关，这与高水平表达TIMP - 2的巨噬细胞和成纤维细胞有关。
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