Stashkevich M A, Khomutov E V, Shatova O P, Dumanskiĭ Iu V, Zinkovich I I
Ukr Biokhim Zh (1999). 2013 Jul-Aug;85(4):94-7.
In blood plasma of 8 healthy volunteers with resuspended lymphocytes incubated with 5-fluorouracil (5-FU) the drug distribution between cells and liquid was assessed by means of HPLC. Rapid accumulation of 5-FU in lymphocytes was proved (the drug concentration on the 3-rd minute is 2.5-fold higher than in plasma) as well as the absence of temporal changes of 5-FU content both in lymphocytes and blood plasma during 30 minutes of experiment.
在8名健康志愿者的血浆中，将淋巴细胞重悬后与5-氟尿嘧啶（5-FU）一起孵育，通过高效液相色谱法评估药物在细胞和液体之间的分布。结果证明5-FU在淋巴细胞中迅速蓄积（第3分钟时药物浓度比血浆中高2.5倍），并且在30分钟的实验过程中，淋巴细胞和血浆中5-FU的含量均未出现随时间的变化。
