双金属接力催化合成螺环脒和螺环缩醛。
Synthesis of spiroaminals and spiroketals with bimetallic relay catalysis.
机构信息
Key Lab for Colloid and Interface Chemistry of Education Ministry School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, China.
出版信息
Org Lett. 2014 Jan 3;16(1):22-5. doi: 10.1021/ol4033286. Epub 2013 Dec 9.
PMID:24320191
Abstract
A novel tandem metal relay catalytic system was developed by combining gold-catalyzed cycloisomerization with an early transition-metal-catalyzed inverse-electron-demand hetero-Diels-Alder (IED-HDA) reaction. Various biologically important spiroaminals and spiroketals were obtained with very high efficiency under mild conditions.
摘要
发展了一种新型串联金属接力催化体系，将金催化的环异构化反应与早期过渡金属催化的逆电子需求杂[4+2]环加成反应相结合。在温和条件下，以非常高的效率得到了各种具有重要生物活性的螺环氨基醇和螺环缩酮。
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