Pilgramm M, Schumann K
HNO. 1986 Oct;34(10):424-8.
Two rheologically active and 8 vasoactive and metabolically active substances were compared in eight independent studies, some of which were randomised and double blind, on 400 patients who had suffered acute acoustic trauma. The control group was given saline. Spontaneous recovery was excluded as far as possible. The following substances were tested: Dextran 40, hydroxyethyl starch 40/0.5, naftidrofurylhydrogenoxalate, Vinpocetin, betahistine, pentoxifylline, flunaricine, Regeneresen AU 4 and 0.9% saline. All groups showed superior results to the control group in both long-term and short-term tests with respect to hearing gain and tinnitis improvement. The rheologically effective substances showed no statistically significant variations. None of the vasoactive or metabolically active substances used as adjunctive therapy improved the results achieved with rheologically effective substances alone. These results demonstrate that acute acoustic trauma can be most effectively treated by rheologically active substances; vasoactive and metabolically active substances are unnecessary. Hyperbaric oxygenation is advantageous as an adjunctive therapy.
在八项独立研究中，对400名急性声创伤患者比较了两种流变学活性物质以及8种血管活性和代谢活性物质，其中一些研究为随机双盲试验。对照组给予生理盐水。尽可能排除自发恢复的情况。测试了以下物质：右旋糖酐40、羟乙基淀粉40/0.5、草酸萘呋胺酯、长春西汀、倍他司汀、己酮可可碱、氟桂利嗪、Regeneresen AU 4和0.9%生理盐水。在听力增益和耳鸣改善方面，所有组在长期和短期测试中均显示出优于对照组的结果。流变学有效物质未显示出统计学上的显著差异。用作辅助治疗的血管活性或代谢活性物质均未改善仅使用流变学有效物质所取得的结果。这些结果表明，急性声创伤最有效的治疗方法是使用流变学活性物质；血管活性和代谢活性物质并非必需。高压氧作为辅助治疗是有益的。
