Department of Radiation Oncology, IRCCS CROB, 1 Padre Pio Street, 85028 Rionero in Vulture, PZ, Italy.
Med Phys. 2013 Nov;40(11):111725. doi: 10.1118/1.4824056.
To evaluate the usefulness of a six-degrees-of freedom (6D) correction using ExacTrac robotics system in patients with head-and-neck (HN) cancer receiving radiation therapy.
Local setup accuracy was analyzed for 12 patients undergoing intensity-modulated radiation therapy (IMRT). Patient position was imaged daily upon two different protocols, cone-beam computed tomography (CBCT), and ExacTrac (ET) images correction. Setup data from either approach were compared in terms of both residual errors after correction and punctual displacement of selected regions of interest (Mandible, C2, and C6 vertebral bodies).
On average, both protocols achieved reasonably low residual errors after initial correction. The observed differences in shift vectors between the two protocols showed that CBCT tends to weight more C2 and C6 at the expense of the mandible, while ET tends to average more differences among the different ROIs.
CBCT, even without 6D correction capabilities, seems preferable to ET for better consistent alignment and the capability to see soft tissues. Therefore, in our experience, CBCT represents a benchmark for positioning head and neck cancer patients.
评估使用 ExacTrac 机器人系统在接受放射治疗的头颈部(HN)癌症患者中进行六自由度(6D)校正的有效性。
对 12 例接受调强放疗(IMRT)的患者进行局部定位准确性分析。根据两种不同的方案,即锥形束 CT(CBCT)和 ExacTrac(ET)图像校正,每天对患者的位置进行成像。从这两种方法中的任何一种获得的定位数据,均在经过校正后的残余误差和选定感兴趣区域(下颌骨、C2 和 C6 椎体)的精确位移方面进行了比较。
两种方案在初始校正后均能达到相当低的残余误差。两种方案之间观察到的移位向量差异表明,CBCT 倾向于以牺牲下颌骨为代价,更多地加权 C2 和 C6,而 ET 则倾向于平均化不同 ROI 之间的更多差异。
即使没有 6D 校正能力,CBCT 似乎也优于 ET,因为它具有更好的一致性和显示软组织的能力。因此,根据我们的经验,CBCT 是头颈部癌症患者定位的基准。