Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Heart and Stroke Centre for Stroke Recovery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
J Am Geriatr Soc. 2013 Dec;61(12):2181-2185. doi: 10.1111/jgs.12541. Epub 2013 Dec 9.
To compare the validity of the Montreal Cognitive Assessment (MoCA) with the criterion standard of standardized neuropsychological testing and to compare the convergent validity of the MoCA with that of existing screening tools and global measures of cognition.
Cross-sectional observational study.
Tertiary care hospital-based cognitive neurology subspecialty clinic.
A convenience sample of 107 individuals with mild Alzheimer's disease (AD, n=75) or mild cognitive impairment (MCI, n=32) from the Sunnybrook Dementia Study.
In addition to the MoCA, all participants completed the Mini-Mental State Examination (MMSE), the Mattis Dementia Rating Scale (DRS), and detailed neuropsychological testing.
Convergent validity was supported, with MoCA scores correlating well with the MMSE (correlation coefficient (r)=0.66, P<.001) and the DRS (r=0.77, P<.001) and the MoCA better associated with the DRS than did the MMSE. Criterion validity was supported, with MoCA subscores according to cognitive domain correlating well with analogous neuropsychological tests and, in the case of memory (area under the receiver operating characteristic curve (AUC)=0.86), executive (AUC=0.79), and visuospatial function (AUC=0.79), being reasonably sensitive to impairment in those domains.
The MoCA is a valid assessment of cognition that shows good agreement with existing screening tools and global measures (convergent validity) and was superior to the MMSE in this regard. The MoCA domain-specific subscores align with performance on more-detailed neuropsychological tests, suggesting not only good criterion validity for the MoCA, but also that it may be useful in guiding further neuropsychological testing.
比较蒙特利尔认知评估（MoCA）与标准化神经心理学测试的标准比较，并比较 MoCA 的收敛有效性与现有筛选工具和全球认知测量的收敛有效性。
横断面观察性研究。
基于三级保健医院的认知神经病学亚专科诊所。
来自 Sunnybrook 痴呆研究的 107 名轻度阿尔茨海默病（AD，n=75）或轻度认知障碍（MCI，n=32）的便利样本。
除了 MoCA，所有参与者还完成了简易精神状态检查（MMSE），Mattis 痴呆评定量表（DRS）和详细的神经心理学测试。
收敛有效性得到支持，MoCA 评分与 MMSE（相关系数（r）=0.66，P<.001）和 DRS（r=0.77，P<.001）高度相关，MoCA 与 DRS 的相关性优于 MMSE。标准有效性得到支持，MoCA 认知域的子评分与类似的神经心理学测试密切相关，并且在记忆方面（接受者操作特征曲线下的面积（AUC）=0.86），执行功能（AUC=0.79）和视觉空间功能（AUC=0.79），在这些领域的损伤方面具有相当的敏感性。
MoCA 是一种有效的认知评估工具，与现有的筛选工具和全球测量（收敛有效性）具有良好的一致性，在这方面优于 MMSE。MoCA 的特定领域子评分与更详细的神经心理学测试的表现一致，这不仅表明 MoCA 具有良好的标准有效性，而且还表明它可能有助于指导进一步的神经心理学测试。
